Aims To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma.
Methods We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients.
Results SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression).
Conclusion Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.
- uveal melanoma
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Presented in part at the World Molecular Imaging Conference, 8–11 September 2010, Kyoto, Japan.
Funding This work was supported by a National Research Foundation of Korea Grant funded by the Korean Government (2009-0077504).
Competing interests None declared.
Ethics approval This study was conducted with the approval of the Yonsei University College of Medicine.
Provenance and peer review Not commissioned; externally peer reviewed.