Background Polymorphisms of CC chemokine receptor 6 (CCR6) genes have recently been reported to be associated with the susceptibility to several immune-related diseases. This study was conducted to examine the association of CCR6 with Behçet's disease (BD) in two Chinese Han populations.
Methods A total of 473 patients with BD and 725 healthy controls from two Chinese Han populations were genotyped by the PCR-restriction fragment length polymorphism method. Hardy–Weinberg equilibrium was tested using the χ2 test. Genotype frequencies were estimated by direct counting. Allele and genotype frequencies were compared between patients and controls using the χ2 test.
Results The genotype and allele frequencies of rs3093024, rs6902119, rs3093023 and rs2301436 were not different between patients with BD and healthy controls. Analysis according to gender and clinical findings including oral ulcer, genital ulcer, skin lesions and arthritis did not show any association of the four tested polymorphisms with these parameters.
Conclusions The tested CCR6 gene polymorphisms are not associated with the susceptibility to BD in the tested Chinese Han populations.
- Behçet's disease
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Funding This work was supported by Natural Science Foundation Major International (Regional) Joint Research Project (30910103912), Key Project of Health Bureau of Chongqing, Project of Medical Science and Technology of Chongqing, Key Project of Natural Science Foundation of Chongqing (CSTC, 2009BA5037), Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003), Program for the Training of a Hundred Outstanding S&T Leaders of Chongqing Municipality and Fund for PAR-EU Scholars Program.
Competing interests None.
Patient consent Obtained.
Ethics approval This study was conducted with the approval of the Ethics Committee of Zhongshan Ophthalmic Center and the First Affiliated Hospital of Chongqing Medical University. All experimental procedures were conducted in accordance with the tenets of the Declaration of Helsinki.
Provenance and peer review Not commissioned; externally peer reviewed.