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Original article
Does β-catenin have a role in pathogenesis of sebaceous cell carcinoma of the eyelid?

Abstract

Aim Expression of β-catenin in sebaceous cell carcinoma (SbCC) of the eyelid and its correlation with histopathological features.

Method 48 cases of SbCC were analysed immunohistochemically using monoclonal β-catenin antibody and the results correlated with tumour size, histopathological differentiation, orbital invasion and pagetoid spread.

Resuts Cytoplasmic overexpression of β-catenin was seen in 66% cases of SbCC which correlated positively with tumour size, orbital invasion and pagetoid spread. This correlation was found to be significant in tumour size >2 cm (p=0.242). Nuclear staining was not observed in any of the cases.

Conclusion Cytoplasmic overexpression of β-catenin was observed in the majority of the cases of SbCC of eyelid, and this correlated significantly with tumour size. The authors therefore hypothesise that β-catenin overexpression in SbCC of eyelid may be a result of Wnt/β-catenin pathway dysregulation. However, its role both in the development of sebaceous cell carcinoma of the eyelid as well as its prognosis needs to be explored further.

  • Eyelid
  • sebaceous cell carcinoma
  • β-catenin
  • Immunohistochemistry
  • Wnt/β-catenin signalling pathway
  • pathology
  • neoplasia

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