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Reactivation of acute retinal necrosis after flu H1N1 vaccination
  1. Aniki Rothova1,
  2. Jolanda D F de Groot1,2,
  3. Tana Mudrikova3
  1. 1Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
  2. 2Department of Virology, University Medical Center Utrecht, Utrecht, The Netherlands
  3. 3Department of infectious diseases, University Medical Center Utrecht, Utrecht, The Netherlands
  1. Correspondence to Professor Aniki Rothova, Department of Ophthalmology, University Medical Center Utrecht, E.03-136, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands; a.rothova{at}

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Varicella zoster virus (VZV) causes latent human infection, and its reactivations have been associated with insufficient cellular immunity. Occasional studies have linked a reactivation of VZV infection to vaccination against other (non-herpes) viruses, specifically flu vaccination.1–3 VZV-related acute retinal necrosis (ARN) is a devastating disease with poor visual prognosis, during which necrotic areas develop in the peripheral retina and rapidly progress. The recent hypothesis on ARN pathogenesis assumes the presence of the latent virus in the neural tissue and attributes the development of ARN to the reactivation of the virus due to a (temporary) decrease in cellular immunity.

We report on a recurrence of bilateral VZV-associated panuveitis following vaccination against flu H1N1 in a 60-year-old male patient with previous VZV-induced ARN after …

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  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; not externally peer reviewed.