Article Text

Download PDFPDF
Original article
Distress, depression and coping in HLA-B27-associated anterior uveitis with focus on gender differences
  1. S M Maca1,
  2. A W Schiesser2,
  3. A Sobala1,
  4. K Gruber3,
  5. G Pakesch4,
  6. C Prause5,
  7. T Barisani-Asenbauer1
  1. 1Department of Ophthalmology, Medical University Vienna, Vienna, Austria
  2. 2Department of Psychology, Sigmund Freud University, Vienna, Austria
  3. 3Hogrefe Verlag, Vienna, Austria
  4. 4Department of Psychiatry, Medical University Vienna, Vienna, Austria
  5. 5Department of Pediatric Psychiatry, Medical University Vienna, Vienna, Austria
  1. Correspondence to Professor Talin Barisani-Asenbauer, Laura Bassi Centre for Expertise Ocuvac, Centre for Pathophysiology, Immunology & Infectiology, Medical University of Vienna, Kinderspitalgasse 15, 1090 Wien Austria; ocuvac{at}


Background/aims To evaluate depression, coping with disease and stress, and the subjective impression of distress and/or life events as triggers for recurrences in HLA-B27-associated anterior uveitis (B27-AU), with attention to gender-specific characteristics.

Methods 171 patients with a history of B27-AU responded to a postal survey performed between January 2006 and April 2008 using standardised psychological questionnaires: Beck Depression Inventory, Freiburg Questionnaire on Coping with Illness, and Stress Coping Inventory.

Results Patients with B27-AU differed from healthy controls showing more depressive symptoms (Beck Depression Inventory, 31.6%), applying characteristic disease coping as well as negative stress coping strategies. Female B27-AU patients tended to react with depression and male patients to use negative stress coping strategies. 57.9% of patients believed that psychological distress was a trigger for relapses, and 34.5% stated specific life events. Together, this group of patients achieved higher depression scores and used more negative disease and stress coping styles than patients without perception of distress.

Conclusion Patients with B27-AU patients exhibited significant psychopathology concerning depression and disease coping. Distress and life events were subjectively suspected to be a trigger. By imparting knowledge to the patients on probable development of depressive moods and the role of stress/life events as trigger for relapses, as well as offering behaviour therapy to optimise coping, may help patients to cope better with B27-AU.

  • Depression
  • coping skills
  • distress
  • gender
  • anterior uveitis
  • inflammation

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Dr S M Maca is currently working at the Hietzing Hospital, Vienna, Austria.

  • Funding This work has been partly supported by Kampf der Blindheit (Association for Prevention of Blindness) in Vienna. The sponsor was not involved in the design or conduct of the research project.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the Ethics Committee of the Medical University Vienna Borschkegasse 8b/6 A-1090 Vienna Austria and in accordance with the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.