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We read with great interest the article by Treumer et al in the January 2010 issue of the journal, regarding the dual action of subretinal injection of recombinant tissue plasminogen activator (rtPA) and bevacizumab associated with pneumatic displacement in treating submacular haemorrhage secondary to age-related macular degeneration.1 Injecting both bevacizumab and rtPA in subretinal,2 or in intravitreal use,3–5 serves the purpose of treating both the subretinal haemorrhage and neovascularisation.
However, rtPA is a serine protease with its catalytic …
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