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  1. Harminder S Dua,
  2. Arun D Singh, Editors-in-Chief

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Primary open-angle glaucoma and WDR36 sequence variance

Frezzotti et al assessed the involvement of WDR36 sequence variance in 34 Italian families affected by primary open-angle glaucoma (POAG). Twenty-five families were affected by high-tension glaucoma (HTG), four by juvenile glaucoma and one by normal tension glaucoma. Five intronic polymorphisms (IVS5+30C/T; IVS12+90 G/T; IVS13+89G/A; IVS16-30A/G; IVS21-75G/A) were identified. In addition, one proband was found to carry the p.D658G mutation. These findings suggest that the WDR36 sequence variance is only rarely observed. Extensive studies are needed to identify the role of genetic factors in the pathophysiology of glaucoma. (See page 624)

Pulse wave velocity in healthy retinal arteries

Kotliar et al analysed time-dependent alterations in retinal vessel diameter by the dynamic vessel analyser in a randomly chosen eye of 10 young (median age 26.0 years) and 10 old (median age 67.0 years) healthy volunteers. Two segments of a retinal artery were measured simultaneously and data analysed to measure retinal artery pulse wave …

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