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Detection of progressive optic nerve head (ONH) changes in follow-up of glaucoma is fundamental. We know from histological studies, however, that non-glaucomatous eyes also undergo a decline in the number of nerve fibres in the ONH with age.1 2 Up-to-date technologies for ONH imaging provide a high resolution and high reproducibility,3–5 and may be more sensitive than are clinicians in detecting ONH changes.6 7 The question arises whether the normal age-dependent decline in the number of optic nerve fibres causes any detectable changes in ONH topography as measured with scanning laser ophthalmoscopy (SLO); this has been suggested in some cross-sectional studies8 9 whereas others have …
Funding Financial support was provided by Silmäsäätiö (The Eye Foundation), the Mary och C. Ehrnrooths Stiftelse, Glaukooma tukisäätiö LUX (the Glaucoma Foundation LUX), and the Helsinki University Hospital Research Fund.
Competing interests None.
Patient consent Obtained.
Ethics approval Ethics approval was provided by the Helsinki Eye Hospital Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.