Article Text

Download PDFPDF
Original article
Association of tear proteins with Meibomian gland disease and dry eye symptoms
  1. Louis Tong1,2,3,
  2. Lei Zhou1,4,
  3. Roger W Beuerman1,2,4,
  4. Shao Zhen Zhao5,
  5. Xiao Rong Li5
  1. 1Singapore Eye Research Institute, Singapore, Singapore
  2. 2Singapore National Eye Centre, Singapore, Singapore
  3. 3Duke-NUS Graduate Medical School, Singapore, Singapore
  4. 4Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  5. 5Tianjin Medical University Eye Center, Tianjin, China
  1. Correspondence to Professor Roger W Beuerman, Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751; rwbeuer{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


Dry eye syndrome is defined as ocular surface dryness and discomfort associated with an abnormal tear film from either tear deficiency or excessive tear evaporation.1 Significant ocular surface damage and visual disability are also common, and it is a healthcare problem that affects millions of people with a prevalence estimated to be as high as …

View Full Text


  • Funding Grants NMRC/0808/2003, NMRC/CPG/002/2003, NMRC/0982/2005 and NMRC/1206/2009 from National Medical Research Council (NMRC), Singapore; an unrestricted grant from Allergan (Irvine, California, USA); and grant 07JCYBJ09800 from Tianjin Committee of Science and Technology Fundamental Research Project.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the Institutional Review Board of the Singapore Eye Research Institute and Tianjin Medical University Eye Center.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Linked Articles

  • At a glance
    Harminder S Dua Arun D Singh