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Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma
  1. Henrike Westekemper1,
  2. Sara Karimi1,
  3. Daniela Süsskind2,
  4. Gerasimos Anastassiou1,
  5. Michael Freistühler1,
  6. Klaus-Peter Steuhl1,
  7. Norbert Bornfeld1,
  8. Kurt-Werner Schmid3,
  9. Florian Grabellus3
  1. 1Department of Ophthalmology, University of Duisburg-Essen, Essen, Germany
  2. 2Department of Ophthalmology, Eberhard-Karls University Tübingen, Tübingen, Germany
  3. 3Institute of Pathology and Neuropathology, University of Duisburg-Essen, Essen, Germany
  1. Correspondence to Dr Florian Grabellus, Institute of Pathology and Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, Germany; florian.grabellus{at}

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In the differential diagnosis of conjunctival melanocytic lesions, HMB45, S100 and Melan-A (MART-1) became the most important immunohistological antigens that help to distinguish melanomas from benign melanocytic lesions of the conjunctiva.1 S100, an acidic protein, and Melan-A, a melanosomal antigen, both mark the extension of a melanocytic lesion.2 3 Jakobiec et al showed that S100 A1 improves the diagnostic assessment of conjunctival nevi and melanomas.2 HMB45, a cytoplasmic oncofetoprotein, is a marker for a low grade of differentiation.4 Its expression is increased in conjunctival melanoma and primary acquired melanosis (PAM) with atypia.1 HMB 45, Melan-A, S100 and Ki67 as a proliferation index became part of the …

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  • Funding The Medical Faculty of the University Duisburg-Essen funded the study.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by the Local Ethics Committee, Medical Faculty of the University of Duisburg-Essen. Germany.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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