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Prostaglandin E2 suppresses polyinosine–polycytidylic acid (polyI:C)-stimulated cytokine production via prostaglandin E2 receptor (EP) 2 and 3 in human conjunctival epithelial cells

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  • The work described in the present paper was carried out in collaboration with Ono Pharmaceutical Co., Ltd., who supplied ONO-AE-259, ONO-AE-248 and ONO-AE-329 used in this study.

  • Funding This work was supported in part by grants-in-aid for scientific research from the Japanese Ministry of Health, Labour and Welfare and the Japanese Ministry of Education, Culture, Sports, Science and Technology, and research grants from the Kyoto Foundation for the Promotion of Medical Science, the Intramural Research Fund of Kyoto Prefectural University of Medicine and the Shimizu Foundation.

  • Competing interests None to declare.

  • Patient consent Obtained.

  • Ethics approval This study was approved by the institutional review board at Kyoto Prefectural University of Medicine, Kyoto, Japan. All experimental procedures were conducted in accordance with the tenets of the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.