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The efficacy of oral ivermectin for the treatment of chronic blepharitis in patients tested positive for Demodex spp.
  1. Pedro Antonio Nogueira Filho1,
  2. Rossen Mihaylov Hazarbassanov2,
  3. Ana Beatriz Diniz Grisolia1,
  4. Henrique Baltar Pazos1,
  5. Igor Kaiserman3,
  6. José Álvaro Pereira Gomes1,4
  1. 1Suel Abujamra Institute (ISA), São Paulo (SP), Brazil
  2. 2Department of Ophthalmology of the Federal University of São Paulo (UNIFESP), São Paulo (SP), Brazil
  3. 3Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel
  4. 4Federal University of São Paulo (UNIFESP), São Paulo (SP), Brazil
  1. Correspondence to Associate Professor José Álvaro Pereira Gomes, Federal University of São Paulo, Rua Sabará, n 566, conjunto 43-01239-010, São Paulo/SP, Brazil; japgomes{at}

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Demodex folliculorum and D brevis are common ectopic parasites that inhabit the pilosebaceous units of the human skin. They are associated with dermatological problems such as acne, rosacea and folliculitis.1 In ophthalmology, they are considered an aetiological factor of chronic blepharitis, meibomian gland dysfunction and ocular surface inflammation. Pathogenesis is controversial as Demodex can also be found in many asymptomatic patients. In this study, we aimed to investigate the efficacy and safety of the oral use of ivermectin in the treatment of chronic, recalcitrant blepharitis.

Patients diagnosed as having chronic symptomatic blepharitis resistant to conventional treatment were included (figure 1A). The participants provided written informed consent, and the study was approved by the institutional review board/ethics committee and followed the tenets of the Declaration of Helsinki. All patients underwent a thorough ophthalmic examination, including tear break-up time (BUT), symptoms' questionnaire and ocular surface disease index (OSDI), and were tested for the presence …

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  • This study was carried out at the Suel Abujamra Institute, ISA, São Paulo (SP), Brazil, in partnership with the Department of Ophthalmology of the Federal University of São Paulo (UNIFESP), São Paulo (SP), Brazil.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the Medical Ethics Committee Suel Abujamra Institute.

  • Provenance and peer review Not commissioned; not externally peer reviewed.