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Macular edema associated with hydrochlorothiazide therapy
  1. P Iacono1,
  2. M Battaglia Parodi2,
  3. F Bandello2
  1. 1Fondazione G. B. Bietti per l'Oftalmologia, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
  2. 2Department of Ophthalmology Clinic, Azienda Ospedaliero-Universitaria of Udine, Udine, Italy
  1. Correspondence to Pierluigi Iacono, Department of Ophthalmology, University of Udine, Piazza S. M. Misericordia, 33100 Udine, Italy; pierluigi.iacono{at}

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In February 2006, a 53-year-old man with progressive and bilateral blurred vision was admitted to the outpatient department of the Eye Clinic of Udine.

His general history revealed essential hypertension for which he had been treated with hydrochlorothiazide 25 mg/day for the past 6 months. After examination, the following was revealed: the best corrected visual acuity (BCVA) in the right eye and that in the left eye were 20/63 and 20/32, respectively. Amsler grid examination revealed metamorphopsia in both eyes. Anterior segment examination result was unremarkable. Fundus examination through clear vitreous showed bilateral macular thickening not associated with cystoid spaces at the fovea. A fluorescein angiogram (FA) showed minimal staining of the macular area without late leakage (figure 1). The electroretinogram and the electroculogram were normal in both eyes. The optical coherence tomographic (OCT) scan obtained through the fovea disclosed bilaterally fluid-filled spaces in the macular region without vitreoretinal traction (figure 2A).

Figure 1

FA showed bilaterally in the early frame minimal staining of the macular area. In the late phases of the FA, no leakage was detected.

Figure 2

(A) OCT scan obtained through the fovea disclosed …

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  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.