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- Amniotic membrane transplantation
- penetrating keratoplasty
- corneal melting disorders
- corneal ulceration
- corneal wound healing
- ocular surface
In cases of severe corneal melting, immediate penetrating keratoplasty (PK) can be required but is accompanied by a high prevalence of complications due to ongoing inflammatory stimuli and wound-healing disorders. In these situations, the properties of amniotic membrane (AM) including promotion of epithelial healing as well as antiangiogenic, anti-infectious, antiscarring and immunemodulatory effects can be beneficial. In the context of PK and AM transplantation (AMT) different surgical approaches are possible: (1) AMT prior to PK; (2) PK with simultaneously performed AM patch, as described in this study; and (3) AMT after PK. Potential advantages of a simultaneous AMT with PK may include the following. First, epitheliotrophic effects of the AM promote wound healing and epithelialisation of the graft and therefore allow early topical steroid application.1 Second, immune-modulatory …
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.