Aims To report the clinical features and causative virus of bilateral acute retinal necrosis (BARN) with a long interval after the initial onset.
Methods The causative virus and clinical features were retrospectively investigated in four patients with delayed-onset BARN with an interval of more than 3 years after the onset of the disease in the initially affected eye.
Results The intervals between the initially affected eye and the latter affected eye of the four cases were 8 years 7 months, 19 years 3 months, 9 years 7 months and 3 years 6 months. The fourth patient developed a second recurrence in the latter affected eye 17 years 6 months after the initial inflammation in the fellow eye. In all four cases, the same virus species, either varicella-zoster virus or herpes simplex virus, was detected in both eyes by PCR or antibody detection. In all cases, the final best-corrected visual acuity of the latter affected eye (20/20, 18/20, 20/20 and 12/20, respectively) was better than that of the initially affected eye (20 cm hand motion, light perception-negative, light perception-negative and light perception-positive, respectively).
Conclusion The present findings indicate that delayed-onset BARN in the fellow eye was caused by the same herpes virus species that induced the disease in the first affected eye.
- Acute retinal necrosis
- varicella-zoster virus
- herpes simplex virus
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Competing interests None.
Ethics approval This study was conducted with the approval of the Ethics Committee in Tokyo Medical University Hospital.
Provenance and peer review Not commissioned; externally peer reviewed.
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