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A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients
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  • Published on:
    Re:Non-inferiority or superiority?

    We would like to thank Dr. Geitzenauer for his comments and concerns regarding our study.

    As he has pointed out, in a non-inferiority study there is potential for bias which may narrow down the difference in efficacy. Therefore, conducting a superiority study simultaneously would be difficult, unless sufficient quality is ensured during study planning, conduct as well as data analysis.

    However, our st...

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    Conflict of Interest:
    None declared.
  • Published on:
    Non-inferiority or superiority?

    Dear editors,

    Takamura et al. report in a recent edition of the BJO about a "multi- center, randomised, double-masked, parallel study" which leads to both a non-inferiority and a superiority claim of the ophthalmic solution being tested (diquafosol ophthalmic solution).(Reference 1) From a methodological standpoint, the conclusions reached by the authors are not in agreement with current accepted standards in th...

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    Conflict of Interest:
    None declared.