Article Text

Download PDFPDF
Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina
  1. Julio A Urrets-Zavalia1,
  2. Nicolas Crim1,
  3. Erna G Knoll1,2,
  4. Fernando A Esposito1,
  5. Elizabeth Collino3,
  6. Maria E Urrets-Zavalia4,
  7. Graciela Saenz-de-Tejada3,
  8. Juan Ignacio Torrealday1,
  9. Horacio M Serra5,
  10. Clare Gilbert6
  1. 1Department of Ophthalmology, University Clinic Reina Fabiola, Universidad Católica de Córdoba, Argentina
  2. 2Department of Ophthalmology, Hospital Materno Neonatal Ramon Carrillo, Córdoba, Argentina
  3. 3Department of Neonatology, Hospital Materno Neonatal Ramon Carrillo, Córdoba, Argentina
  4. 4School of Medicine, Universidad Católica de Córdoba, Argentina
  5. 5Faculty of Chemical Sciences, Universidad Nacional de Córdoba, CIBICI-CONICET, Córdoba, Argentina
  6. 6International Centre for Eye Health, Faculty of Infectious Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
  1. Correspondence to Dr Julio A Urrets-Zavalia, Department of Ophthalmology, Clinica Universitaria Reina Fabiola, Universidad Católica de Córdoba, Oncativo 1248, Córdoba 5000, Argentina; julioaurrets{at}


Aims To assess the impact of different oxygenation policies on the rate and severity of retinopathy of prematurity (ROP).

Methods Between January 2003 and December 2006, infants of 1500 g birthweight (BW) or less and/or 32 weeks gestational age (GA) or less, and larger, more mature infants with risk factors for ROP were examined through three different time periods: period 1: high target oxygen saturation levels (88–96%) and treatment at threshold ROP; period 2: low target oxygen saturation levels (83–93%) and treatment at threshold ROP; period 3: low target oxygen saturation and treatment at type 1 ROP.

Results Type 1 ROP was detected more frequently in babies of 32 weeks GA or less (50/365, 13.7%) than in more mature babies (15/1167, 1.3%; p<0.001). The rate of type 1 ROP in period 1 was 6.9%; period 2, 3.6% and period 3, 1.8%. Rates of stage 3 ROP declined over time in both BW/GA groups (from 9.0% to 4.1% to 2.0%) as did rates of plus disease (from 7.5% to 3.6% to 1.8%). Mean BW and GA declined from period 1 to period 3, and death rates remained unchanged. 74.4% of babies received all the examinations required; 48.1% of treatments were undertaken after discharge from the neonatal unit.

Conclusions Lower target oxygen saturation was associated with a lower rate of severe ROP without increasing mortality, and changed the characteristics of affected babies. Screening criteria need to remain wide enough to identify all babies at risk of ROP needing treatment.

  • Child health (paediatrics)
  • Public health
  • Retina

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.