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Clinical science
Original article
The relationship between corneal hysteresis and the magnitude of intraocular pressure reduction with topical prostaglandin therapy
  1. Daniel R Agarwal1,
  2. Joshua R Ehrlich1,
  3. Mitsugu Shimmyo2,
  4. Nathan M Radcliffe1
  1. 1Department of Ophthalmology, Weill Cornell Medical College, New York, New York, USA
  2. 2Department of Ophthalmology, New York Medical College, Valhalla, New York, USA
  1. Correspondence to Nathan M Radcliffe, 1305 York Avenue, New York, NY 10021, USA; nmr9003{at}med.cornell.edu

Abstract

Aims To evaluate corneal hysteresis (CH) and intraocular pressure (IOP) before and after IOP lowering with prostaglandin analogue (PGA) therapy in medication-naïve eyes.

Methods In this retrospective study, we included records from 57 consecutive patients with open angle glaucoma who were initiated on PGA. Patients underwent ocular response analyser measurement with IOP assessment at baseline (untreated) and at follow-up (treated).

Results Median follow-up time between IOP measurements was 1.4 (range 0.4–13.5) months. IOP was reduced by 3.2 mm Hg (18.8%) from 17.0 to 13.8 mm Hg (p<0.001). CH increased by 0.5 mm Hg (5.2%) from 9.7 to 10.2 mm Hg (p=0.02). Baseline CH (but not baseline central corneal thickness) was a significant predictor of the magnitude of IOP reduction, with patients in the lowest quartile of CH (mean 7.0 mm Hg) experiencing a 29.0% reduction in IOP while those in the highest CH quartile (mean 11.9 mm Hg) experienced a 7.6% reduction in IOP (p=0.006). A multivariate analysis controlling for baseline IOP demonstrated that baseline CH independently predicted the magnitude of IOP reduction with PGA therapy in both per cent (ß=3.5, p=0.01) and absolute (ß=0.6, p=0.02) terms.

Conclusion Although CH is influenced by IOP, baseline CH is independently associated with the magnitude of IOP reduction with PGA therapy.

  • Corneal hysteresis
  • ocular response analyser
  • corneal thickness
  • glaucoma
  • prostaglandin analogue
  • intraocular pressure
  • diagnostic tests/investigation
  • treatment medical

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

https://doi.org/10.1136/bjo.2010.196899

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    Footnotes

    • Funding This work was supported in part by the American Glaucoma Society and the Medical Student Training in Aging Research Program.

    • Competing interests All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare that: (1) DRA, JRE, MS and NMR have instrument support from Reichert, Inc. for the submitted work; (2) NMR is a consultant to Allergan and Alcon; and (3) the authors have no non-financial interests that may be relevant to the submitted work.

    • Ethics approval This study was conducted with the approval of the Institutional Review Board at Weill Cornell Medical College and New York Presbyterian Hospital.

    • Provenance and peer review Not commissioned; externally peer reviewed.