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Reproducibility of segmentation error correction in age-related macular degeneration: Stratus versus Cirrus OCT
  1. Ilse Krebs1,2,
  2. Stefan Hagen1,2,
  3. Eva Smretschnig1,
  4. Irene Womastek3,
  5. Werner Brannath3,
  6. Susanne Binder1,2
  1. 1The Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria
  2. 2Department of Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria
  3. 3Core Unit for Medical Statistics and Informatics, Medical University, Vienna, Austria
  1. Correspondence to Dr Ilse Krebs, Department of Ophthalmology, Rudolf Foundation Clinic, Juchgasse 25, Vienna 1030, Austria; ilse.krebs{at}


Introduction The accuracy of retinal thickness measurement in age-related macular degeneration by optical coherence tomography (OCT) is affected by threshold algorithm line errors. The reproducibility of error correction in Stratus and Cirrus OCT should be examined.

Methods OCT examinations of a consecutive series of 104 patients with neovascular age-related macular degeneration included in another study were reviewed. 72 eyes exhibited failures in Stratus OCT and 32 eyes in Cirrus OCT and were included in this new study. Algorithm line failures of Stratus OCT (retinal thickness program) and Cirrus OCT (Macular Cube 512×128 program) were corrected independently twice by two ophthalmologists and two residents, respectively, using the Stratus and Cirrus OCT built-in software. Reproducibility was assessed by the interclass correlation coefficient (ICC).

Results The corrected values of central retinal thickness were significantly lower than the automated measured values in Stratus OCT for all examiners (p<0.001), while in Cirrus OCT the differences were not significant (p=0.06–0.09). For Stratus OCT, the ICC for central retinal thickness was 0.991 and 0.997 for the experienced ophthalmologists and 0.89 and 0.97 for the residents. For Cirrus OCT, the ICC was 1.0 and 1.0 for the experienced ophthalmologists and 0.99 and 0.95 for the residents.

Conclusion The reproducibility of threshold algorithm line failure correction was good overall in Stratus and Cirrus OCT and can therefore be recommended to improve retinal thickness measurement, particularly when experienced examiners perform the corrections.

  • Age-related macular degeneration
  • retinal thickness
  • optical coherence tomography
  • spectral domain OCT
  • choroidal Neovascularisation
  • macula, neovascularisation
  • imaging

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  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Ethics Committee of the City of Vienna.

  • Provenance and peer review Not commissioned; externally peer reviewed.