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Relapsing migratory idiopathic orbital inflammation: six new cases and review of the literature
  1. Noa Avni-Zauberman1,
  2. Devjyoti Tripathy2,
  3. Nachum Rosen1,
  4. Guy J Ben Simon1
  1. 1Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  2. 2Oculoplastics & Orbital Services, Priyamvada Birla Aravind Eye Hospital, Kolkata, India
  1. Correspondence to Guy J Ben Simon, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel; guybensimon{at}


Aims To present a case series of relapsing migratory idiopathic orbital inflammation.

Patients and methods Case series and review of the literature. The medical records of six patients with recurrent orbital myositis or idiopathic inflammation at different sites treated at the Goldschleger Eye Institute between April 2006 and December 2009 were collected and analysed; one patient treated at the orbital service in Priyamvada Birla Aravind Eye Hospital, Kolkata, India, was also included (June 2008 to August 2010). Orbital biopsy was performed in patients who failed to respond to steroids treatment.

Results A total of six patients with recurrent episodes of orbital myositis or inflammation were identified. Four patients had orbital myositis of one extraocular muscle at the initial episode and recurrent myositis of a different extraocular muscle on the contralateral orbit. One patient had recurrent myositis of a different extraocular muscle on the same orbit. Two patients had a third episode of recurrence on a different site, that is, an extraocular muscle or an eyelid. One patient had eyelid and soft tissue involvement on one orbit and recurrence of orbital myositis on the contralateral eyelid. Histological findings in the latter case showed small perivascular lymphocytic aggregates and scattered histiocytes. The mean time for recurrence was 7.2 months. All patients were treated successfully with oral steroids and/or intralesional triamcinolone injection.

Conclusions Idiopathic orbital inflammation or orbital myositis can recur on a different extraocular muscle and on the contralateral orbit. These cases can be successfully treated with orally administered or intralesionally injected steroids.

  • Orbit
  • inflammation

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  • Funding The study was supported in part by the Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Sheba Medical Center, Tel Hashomer.

  • Provenance and peer review Not commissioned; externally peer reviewed.