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Primary open-angle glaucoma (POAG) is an optic neuropathy associated with the loss of retinal ganglion cells. The pathophysiology of the disease is incompletely understood. Increased intraocular pressure (IOP) is the most important risk factor for the disease, although many individuals with elevated IOP never develop glaucoma, and glaucomatous damage can occur despite IOP levels in the normal range. Several large-scale trials have proved that the progression of visual field loss can be retarded by reducing …