Article Text

Download PDFPDF
Original article
Correlation between corneal biomechanical properties, applanation tonometry and direct intracameral tonometry
  1. A-Yong Yu1,
  2. Su-Fang Duan1,
  3. Yun-E Zhao1,
  4. Xing-Yu Li1,
  5. Fan Lu1,
  6. Jianhua Wang2,
  7. Qin-Mei Wang1
  1. 1School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
  2. 2Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA
  1. Correspondence to Dr Qin-Mei Wang, 270 Xueyuan West Road, Wenzhou (325000), Zhejiang, PR China; wqm2{at}


Aim To investigate the correlation between corneal biomechanical properties, applanation tonometry and direct intracameral tonometry.

Methods Patients scheduled for phacoemulsification were enrolled in this prospective observer-masked study. Central corneal thickness (CCT) was obtained with ultrasound pachymetry. Corneal biomechanical properties including corneal hysteresis (CH) and corneal resistance factor (CRF) were measured with the ocular response analyser. Applanation intraocular pressure (IOP) (IOPappla) was measured in the supine position. Intracameral IOP (IOPintra) was measured with a pressure transducer connected to a cannula inserted into the anterior chamber.

Results Fifty-eight eyes of 58 patients were included. There was a significant difference between IOPappla and IOPintra (17.3±4.1 vs 13.8±4.7 mm Hg, p<0.001). CCT was significantly correlated with CH and CRF (p<0.01). Univariate regression analysis revealed IOPappla was significantly correlated with CCT and CRF (p<0.05). IOPintra had no significant association with the corneal properties (p>0.05). Multivariate regression analysis revealed IOPappla=10.43+2.69CRF–1.99CH (p<0.001) and the difference between IOPappla and IOPintra (ΔIOP)=−1.57+0.55CRF (p=0.032).

Conclusion The mean difference between IOPappla and IOPintra was 3.5 mm Hg. While IOPappla was correlated with the corneal biomechanical properties of CH and CRF, IOPintra was not. IOPappla was correlated more with the corneal biomechanical properties assessed by the ocular response analyser than with CCT alone.

  • Anatomy
  • anterior chamber
  • clinical trial
  • colour vision
  • cornea
  • imaging
  • intraocular pressure
  • lens and zonules
  • ocular surface
  • optics and refraction
  • tears
  • treatment surgery

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding This study was supported by research grants from the Chinese National Key Technologies R&D Program, Beijing, China (2007BAI18B09 to FL) and the Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents (to FL).

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval The research protocol adhered to the tenets of the Helsinki Declaration and was approved by the local ethics committee (ethics committee at the Eye Hospital, Wenzhou Medical College, 270 Xueyuan West Road, Wenzhou, Zhejiang, China).

  • Provenance and peer review Not commissioned; externally peer reviewed.

Linked Articles

  • At a glance
    Harminder Singh Dua Arun D Singh