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Footnotes

  • Funding This work was supported by FAPESP, grant number 98/11205, 06/53772-7 and CNPq 03763/2010-8.

  • Competing interests None.

  • Ethics approval The Ethics Committee at the Instituto de Ciências Biomédicas Universidade de São Paulo.

  • Provenance and peer review Commissioned; internally peer reviewed.

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