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Review of endophthalmitis following Boston keratoprosthesis type 1
  1. Marie-Claude Robert,
  2. Krystel Moussally,
  3. Mona Harissi-Dagher
  1. Department of Ophthalmology, Centre Hospitalier de l'Université de Montréal (CHUM), Hôpital Notre-Dame, Montréal, Québec, Canada
  1. Correspondence to Dr Mona Harissi-Dagher, Department of Ophthalmology, Notre-Dame Hospital, 1560, rue Sherbrooke Est, Montréal, Québec H2L 4M1, Canada; monadagher{at}


Endophthalmitis remains one of the most damaging and challenging complications following Boston keratoprosthesis type 1 (KPro) surgery. The authors reviewed the literature from 2001 onward to identify cases of endophthalmitis following KPro surgery and present an additional case of endophthalmitis in a patient with Stevens Johnson syndrome. The prevalence of endophthalmitis between 2001 and 2011 was 5.4%. Gram-positive bacteria are the most common agents responsible for endophthalmitis in this patient population while gram-negative bacteria and fungi are emerging pathogens. Risk factors for endophthalmitis include preoperative diagnosis of cicatricial disease and postoperative infectious keratitis, glaucoma drainage device erosion and non-compliance with antibiotic prophylaxis. Additional studies on the prevention and treatment of endophthalmitis are required to improve the overall prognosis of these patients.

  • Boston keratoprosthesis type 1
  • endophthalmitis
  • cornea
  • infection
  • prosthesis

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  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval The study consists of the case reports . Ethics committee/IRB approval is not required for case reports.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The authors will share the original study protocol and the dataset used for the analysis upon request.