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Original article
Corneal biomechanical properties and intraocular pressure measurement in patients with nanophthalmos
  1. Cigdem Altan1,
  2. Necip Kara2,
  3. Okkes Baz1,
  4. Banu Şatana1,
  5. Ahmet Demirok1,
  6. Omer Faruk Yilmaz1
  1. 1Beyoglu Eye Research and Training Hospital, Istanbul, Turkey
  2. 2Kanuni Sultan Suleyman Education and Research Hospital, Department of Ophthalmology, Istanbul, Turkey
  1. Correspondence to Necip Kara, Kartaltepe Mh, Akın Sk, Akın Apt No:8/14, Bakırköy, Istanbul 34001, Turkey; dr.necipkara{at}


Aims To compare the biomechanical properties of the cornea and intraocular pressure (IOP) between patients with nanophthalmos and age-matched controls.

Methods In this prospective, cross-sectional and comparative study, 27 eyes of 27 healthy individuals (control group) and 27 eyes of 27 patients with nanophthalmos (study group) were enrolled. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal compensated intraocular pressure (IOPcc) and Goldmann correlated intraocular pressure (IOPg) were recorded for the right eye of each participant using Reichert Ocular Response Analyser measurements. Also, all participants in this study underwent a standardised ocular examination including IOP measurement with Goldmann applanation tonometry (IOPGAT), central corneal thickness and axial length (AL) assessments.

Results Mean CH in the nanophthalmic eyes and in the control eyes were 13.3±2.4 mm Hg and 11.6±1.7 mm Hg, respectively (p=0.003); mean CRF values in the nanophthalmic and the control eyes were 13.2±1.8 mm Hg and 11.4±1.9 mm Hg, respectively (p=0.001). Mean IOPGAT was 15.2±3.3 mm Hg in the nanophthalmic eyes and 13.4±2.7 mm Hg in the control group (p=0.031); mean IOPg values for the nanophthalmic and the control groups were 17.1±5.3 mm Hg and 14.7±3.5 mm Hg, respectively (p=0.042). Mean IOPcc values in the nanophthalmic and the control group were 13.6±6.1 mm Hg and 14.8±3.2 mm Hg, respectively (p=0.365).

Conclusion The CH, CRF, IOPg and IOPGAT were significantly higher in the nanophthalmic eyes, whereas no significant differences in IOPcc were observed. These findings may be taken into account when measuring IOP values in patients with nanophthalmos.

  • Nanophthalmos
  • corneal hysteresis
  • corneal resistance factor
  • intraocular pressure
  • glaucoma
  • cornea
  • eye (globe)
  • optics and refraction
  • macula

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  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was approved by Beyoglu Eye Education and Research Hospital Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.