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  1. Bilal Hajnajeeb,
  2. Michael Georgopoulos,
  3. Ramzi Sayegh,
  4. Wolfgang Geitzenauer,
  5. Ursula Margarethe Schmidt-Erfurth
  1. Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  1. Correspondence to Professor Michael Georgopoulos, Department of Ophthalmology, Medical University of Vienna, Spitalgasse 23, A-1090 Vienna, Austria; michael.georgopoulos{at}

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We would like to thank Dr Ayata and colleagues1 for their interest in our work2 and their comments and concerns regarding our publication.

  1. Throughout our manuscript, we did not mention that our study was blinded. In contrast, we clearly referred in both the methods and the discussion sections that our work was not blinded giving the explanation for that decision (eg, Discussion: ‘…and the non-blinded form of our study have to be considered.’).

  2. We fully agree with Dr Ayata and colleagues regarding the inappropriate usage of μm2 instead of mm2 unit and thank them for the notification.

  3. We agree with Dr Ayata and colleagues that retinal thickness map is not a real image and some software in the modern optical coherence tomography equipment possibly gives better assessment of the size and shape of the epiretinal membrane (ERM). On the other hand, as we concluded in our work, retinal thickness map gives us a false colour topographic map that can be more helpful with regard to identifying the elevation and the extent of the retinal fold(s), assisting the surgeon to find the best starting point(s) of the peeling process.

  4. Our study is retrospective, as we stated in the methods paragraph, that is, we had no ability to preselect the dye or the surgical technique (like using triamcinolone to stain possibly the remaining vitreous cortex). In addition, the selection of indocyanine green (ICG)-stained maculae was mainly because of its histological proven unique property in staining selectively the exposed internal limiting membrane (ILM).3 Noteworthy, trypan blue could create a noticeable bias by outlining the ERM contour, since it stains both ERM as well as ILM.4

  5. The aim of our work was to find a safe preoperative tool to substitute common dyes (including ICG), not to stress or falsify the effectiveness and safety of ICG. Nevertheless, we have already cited the two identical references4 5 cited by Dr Ayata and colleagues concerning toxicity of retinal dyes in our original paper. Therefore, we certainly did not encourage the readers to use ICG dye in the eye.



  • Linked articles 301659, 300629.

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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