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Professor Hanspeter Esriel Killer et al, in a series of excellent original articles on cerebrospinal fluid (CSF) dynamics in the subarachnoid spaces (SAS) of the optic nerve, holds the view that CSF is compartmentalised within the trabecular SAS of the optic nerve causing stasis or reduced CSF flow.1 As a result, the CSF composition is altered. Increased concentration of molecules such as Lipocalin-type prostaglandin D synthase (L-PGDS) supposedly causes toxic damage to the optic nerve. The ratio …
Competing interests None.
Patient consent This is only a scientific response to article published recently in the BJO.
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