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Resistance, not tachyphylaxis or tolerance
  1. Olli Arjamaa1,
  2. Heikki Minn2
  1. 1Department of Biology, University of Turku, Finland
  2. 2Department of Oncology and Radio Therapy, Turku PET Centre, Turku University Hospital, Turku, Finland
  1. Correspondence to Dr Olli Arjamaa, Department of Biology, Vesilinnanmäki, University of Turku, Turku 20014, Finland; olli.arjamaa{at}

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We read with great interest the editorial ‘Loss of reactivity in intravitreal anti-VEGF therapy: tachyphylaxis or tolerance?’ published recently in the British Journal of Ophthalmology.1 The editorial discussed possible mechanisms behind decreased anti-vascular endothelial growth factor (anti-VEGF) response to neovascular age-related macular degeneration (AMD). Two articles were published in the same issue in which tachyphylaxis was suggested to occur during anti-VEGF treatment of wet AMD.2 ,3 The editorial and these papers stimulated us to comment on the discussion. …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.