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Clinical science
Clinical features of reticular pseudodrusen according to the fundus distribution
  1. Mee Yon Lee1,
  2. Jaemoon Yoon2,
  3. Don-Il Ham2
  1. 1Department of Ophthalmology, Chung-Ang University, College of Medicine, Seoul, Korea
  2. 2Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  1. Correspondence to Dr Don-Il Ham, Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea; oculus{at}


Background To evaluate the morphological features and prevalence of accompanying late age-related macular degeneration (AMD) according to the fundus distribution of reticular pseudodrusen (RPD).

Methods According to the involved area in the fundus, the distribution of RPD was classified as localised, intermediate, or diffuse type. Morphology of RPD was classified as discrete, branching, or confluent pattern. The presence of late AMD was evaluated.

Results 233 eyes of 121 patients with RPD were included. The distribution of RPD was localised, intermediate and diffuse type in 30.9%, 40.3% and 28.8% of eyes, respectively. The discrete, branching and confluent morphological patterns were found in 45.8%, 44.8% and 9.7% of the localised type, and in 0%, 13.8% and 86.2% of the intermediate type, respectively. In contrast, the diffuse type showed only the confluent morphological pattern. The prevalence of accompanying late AMD was 13.9%, 13.8% and 56.7% in the localised, intermediate and diffuse type, respectively, and it was significantly higher in the diffuse type (p<0.05).

Conclusion RPD with diffuse distribution showed a confluent morphological pattern and a high prevalence of late AMD. RPD can be classified by the fundus distribution for the assessment of visual prognosis.

  • Age-related macular degeneration
  • fundus distribution
  • geographic atrophy
  • morphological pattern
  • reticular pseudodrusen

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  • Competing interests None.

  • Ethics approval Ethics approval was provided by the institutional review board of Samsung Medical Center, Seoul, Korea.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The authors declare that some of the study population of this study was previously included in their other article (Clinical characteristics of reticular pseudodrusen in Korean patients, Am J Ophthalmol 2012;153:530-5) because both articles are a retrospective study about reticular pseudodrusen in the same hospital. However, the study design, main outcome measures, inclusion criteria of the study subjects and the study period are different between the two studies.

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