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Relationship between ganglion cell-inner plexiform layer and optic disc/retinal nerve fibre layer parameters in non-glaucomatous eyes
  1. Yih-Chung Tham1,2,
  2. Carol Y Cheung1,2,3,
  3. Victor T Koh1,2,
  4. Ching-Yu Cheng1,2,
  5. Elizabeth Sidhartha1,
  6. Nicholas G Strouthidis1,4,
  7. Tien Y Wong1,2,
  8. Tin Aung1,2
  1. 1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
  2. 2Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore
  3. 3Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore
  4. 4NIHR Biomedical Research Centre at Moorfields NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
  1. Correspondence to Professor Tin Aung, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore; aung.tin{at}


Aims To determine the relationship between macular ganglion cell–inner plexiform layer (GC-IPL) thickness and optic disc/retinal nerve fibre layer (RNFL) parameters in non-glaucomatous eyes measured by spectral-domain optical coherence tomography (SD-OCT).

Methods 491 non-glaucomatous Chinese aged 40–80 years were recruited from a population-based study and underwent standardised ophthalmic examination. SD-OCT was used to measure GC-IPL thickness, optic disc parameters and RNFL thickness. Univariate and multiple linear regression analyses were performed to assess the association between GC-IPL and optic disc/RNFL parameters.

Results In univariate analyses, all RNFL parameters and rim area were significantly correlated with all macular GC-IPL parameters (p<0.001, r=0.12–0.56). In multiple regression analyses, after adjusting for age, gender, disc area, signal strength and axial length, average RNFL thickness (per µm decrease) was most strongly correlated with average GC-IPL thickness (β=−0.30, standardised β=−0.499, p<0.001) compared with other optic disc/RNFL parameters.

Conclusions Our study demonstrated only fair correlations between macular GC-IPL and optic disc/RNFL parameters measured by SD-OCT. This information is important for further evaluation of macular GC-IPL thickness as an additional marker in detecting glaucomatous damage and progression.

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