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Retinoblastoma is the most common primary intraocular tumour in children with an incidence of 1 in 15 000 live births.1 In recent years, intravenous chemoreduction, followed by adjuvant focal treatment, has reduced the number of retinoblastoma cases needing external beam radiotherapy and enucleation.2 Optic nerve involvement is one of the most highly predictive factors for death from this disease.3 Postlaminar tumorous invasion, and tumour presence at the surgical margin of the optic nerve are both considered major prognostic factors for disease dissemination.3 ,4
A 20-month-old patient was diagnosed with sporadic bilateral retinoblastoma, Group C, or Vb endophytic, in the left eye (LE) with local vitreous seeds, and Group D, or Va exophytic, in the right eye (RE) with complete retinal detachment, subretinal and epiretinal seeding, due to a macular tumour adjacent to the optic disc (figure 1A,B).5