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We read with interest the paper by Caramoy et al recently published in the British Journal of Ophthalmology—our attention having been captured by the inclusion of clinical trial design in its title.1 Developments in stem cell treatments and the advent of anti-vascular endothelial growth factor treatments have very much placed ophthalmic clinical trials in the public arena. We feel however that the main conclusion drawn by the authors that ‘clinical trials using central retinal thickness as an endpoint are feasible in terms of sample size needed’ needs to be tempered in the light of the following issues.
Power: Designing a clinical trial with 80% power means that there is a 20% chance of missing …
Contributors OC and CB wrote the article. PJP and CJD edited the OCT and statistical sections respectively.
Competing interests OC receives unrestricted research funding from Novartis. PJP has acted as a consultant for Heidelberg. CB and CJD have no competing interests.
Provenance and peer review Not commissioned; internally peer reviewed.