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Is high-resolution spectral domain optical coherence tomography reliable in nystagmus?
  1. Mervyn G Thomas1,
  2. Anil Kumar1,
  3. John R Thompson2,
  4. Frank A Proudlock1,
  5. Kees Straatman3,
  6. Irene Gottlob1
  1. 1Ophthalmology group, School of Medicine, University of Leicester, Leicester, UK
  2. 2Department of Health Sciences, University of Leicester, Leicester, UK
  3. 3Centre for Core Biotechnology Services, University of Leicester, UK
  1. Correspondence to Professor Irene Gottlob, Ophthalmology group, School of Medicine, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK; ig15{at}le.ac.uk

https://doi.org/10.1136/bjophthalmol-2011-300476

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    Recently, there has been an increased number of studies investigating retinal morphology in infantile nystagmus.1–4 Optical coherence tomography (OCT) studies in achromatopsia have shown progressive retinal changes.1 ,2 ,4 Most OCT software limits segmentation to the retinal nerve fibre layer and overall retinal thickness (RT). However, we have shown that outer nuclear layer (ONL), outer segment (OS) and foveal depth (FD) are important measurements in infantile nystagmus.2 ,5 Intraretinal thicknesses (FD, ONL, inner segment (IS) and OS) can be derived using reflectivity-based segmentation using ImageJ1 (figure 1). External limiting membrane (ELM) and inner–outer segment junction (IS/OS) reflectivity changes have been reported in blue cone monochromatism and achromatopsia. However, it is unclear whether nystagmus allows reproducible OCT measurements of …

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    Footnotes

    • ▸ Additional materials are published online only. To view these files please visit the journal online (http://bjo.bmj.com).

    • Funding The study was supported by the National Eye Research Centre and Ulverscroft foundation.

    • Competing interests None.

    • Ethics approval University Hospital Leicester (UHL) Trust Research & Development.

    • Provenance and peer review Not commissioned; externally peer reviewed.