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I would like to thank Comyn et al for their interest in our published article.1 I agree that different methodologies, different assumptions, or even analyses on different patient collectives might result in a different conclusion or a different sample size needed for randomised clinical trials.
(i and ii) Power: the sample size calculation used with power of 80% was based on studies, such as the Age-Related Eye Disease Study trial.2 Using 90% power, α=0.05 and 10% loss to follow-up, I calculated once more the sample size needed for hypothetical studies (table 1).
(iii) I integrated the findings from Comyn …
Contributors Sole author.
Funding Received research support from Bausch&Lomb, Fluoron GmbH and Alamedics GmbH.
Competing interests None.
Patient consent Obtained.
Ethics approval University of Cologne.