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Branch retinal vein occlusion and optic nerve head topographic parameters: the Singapore Indian eye study
  1. Errol Wei'en Chan1,
  2. Tien Yin Wong1,2,3,
  3. Jiemin Liao1,2,
  4. Carol Yim-lui Cheung2,
  5. Ying Feng Zheng2,
  6. Jie Jin Wang4,5,
  7. Paul Mitchell4,
  8. Seng Chee Loon1,
  9. Seang-Mei Saw2,6,
  10. Tin Aung1,2,3,
  11. Ching-Yu Cheng1,2,6,7
  1. 1Department of Ophthalmology, National University Hospital, National University Health System, Singapore, Singapore
  2. 2Singapore Eye Research Institute, Singapore, Singapore
  3. 3Singapore National Eye Centre, Singapore, Singapore
  4. 4Department of Ophthalmology, Centre for Vision Research, University of Sydney, Westmead, New South Wales, Australia
  5. 5Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
  6. 6Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
  7. 7Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore
  1. Correspondence to Dr Ching-Yu Cheng, Saw Swee Hock School of Public Health, National University of Singapore, Singapore Eye Research Institute 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228, Singapore; ching-yu_cheng{at}


Aim To examine the association between branch retinal vein occlusion (BRVO) and quantitative optic disc topographic parameters.

Methods The Singapore Indian Eye Study (SINDI) is a population-based study of 3400 Singapore Indians aged 40+ years. BRVO was defined and graded from retinal photographs. Optic disc parameters were quantified using the Heidelberg Retinal Tomograph III (HRT III). Associations were evaluated for individual eyes; the generalised estimating equation was used to account for correlation between fellow eyes.

Results 6173 eyes (comprising 19 BRVO) had gradable retinal photographs and HRT images. After controlling for age, gender, and systemic (hypertension, diabetes, myocardial infarction) and ocular factors (intraocular pressure, glaucoma, central corneal thickness, axial length, previous laser photocoagulation), BRVO was associated with larger optic disc area (OR highest vs lowest tertile, 4.70; 95% CI 1.00 to 22.01; p=0.036), larger cup area (OR highest vs lowest tertile, 4.80; 95% CI 1.03 to 22.35; p=0.029) and larger cup–disc area ratio (OR highest vs lowest tertile, 4.44; 95% CI 0.95 to 20.66; p=0.037). After excluding glaucoma eyes, BRVO remained significantly associated with these parameters (p=0.027, p=0.018, p=0.024, respectively).

Conclusions Quantitative optic disc parameters (optic cup and disc area) are associated with BRVO, even in non-glaucomatous eyes. Optic nerve head morphology may play a role in BRVO pathogenesis.

  • Retina
  • Optic Nerve
  • Imaging

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