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In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology
  1. Lucia Pelosini1,
  2. Henry Barnabas Smith1,
  3. John B Schofield2,
  4. Adam Meeckings3,
  5. Anish Dhital1,
  6. Mona Khandwala1
  1. 1Ophthalmology Department, Maidstone & Tunbridge Wells NHS Trust, Maidstone, Kent, UK
  2. 2Histopathology Department, Maidstone & Tunbridge Wells NHS Trust, Maidstone, Kent, UK
  3. 3Michelson Diagnostics Limited, 11A Grays Farm Production Village, Orpington, Kent, UK
  1. Correspondence to Mona Khandwala, Ophthalmology Department, Maidstone & Tunbridge Wells NHS Trust, Hermitage Lane, Maidstone, Kent ME16 9QQ, UK; mona.khandwala{at}


Aim To investigate in vivo optical coherence tomography (OCT) for imaging of periocular basal cell carcinoma (BCC).

Methods Consecutive patients with periocular BCC were prospectively investigated with VivoSight OCT imaging prior to surgical excision. Histology sections were compared with OCT images with regard to lesion measurements (x, y and z dimensions) and histological features.

Results A total of 15 patients with biopsy proven BCC were recruited. The OCT horizontal margins correlated positively with histology (r=0.8 and 0.66, x and y axes) and could be identified in 3/15 (x axis) and 6/15 (y axis) cases. The vertical margin correlation was r=0.43 and BCC depth could be measured in 9/15 cases. The following histological features of BCC could be identified on OCT images: (1) lobular pattern (100%); (2) dilated blood vessels (80%); (3) reflective margins of tumour lobules (100%); and (4) epidermal thinning overlying BCC lobules (100%).

Conclusions This study indicated a strong positive correlation between the margins of periocular BCCs measured using in vivo OCT and histology, and a weak positive correlation with depth of invasion. VivoSight OCT produced high resolution images of BCC morphology. The limitations in horizontal margin measurements could potentially be overcome by design modification of the scanning probe.

  • Eye Lids
  • Imaging
  • Neoplasia
  • Treatment Surgery
  • Pathology

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