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Cognitive function and pseudoexfoliation syndrome. The Beijing Eye Study 2011
  1. Liang Xu1,
  2. Qi Sheng You1,
  3. Ya Xing Wang1,
  4. Jonas B Jonas1,2
  1. 1Beijing Tongren Hospital, Capital University of Medical Science, Beijing Institute of Ophthalmology, Beijing, China
  2. 2Department of Ophthalmology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  1. Correspondence to Prof Liang Xu, MD, and Jost B Jonas, MD, Beijing Institute of Ophthalmology, 17 Hougou Lane, Chong Wen Men, 100005 Beijing, China; E-mail: xlbio1{at}; Phone: +86-10-58265918; Fax: +86-10-6512 5617

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Previous studies have suggested that pseudoexfoliation syndrome could be associated with Alzheimer's disease, since pseudoexfoliation syndrome has some features in common with Alzheimer's disease, in that amyloid-associated proteins occur in association with both diseases.1–3 Since the major limitation of these studies was their design as hospital-based investigations with the potential bias due to the selection of patients, we addressed the question on a potential association between pseudoexfoliation syndrome and Alzheimer's disease in a population-based study. We assessed cognitive function as a measure for Alzheimer's disease.

The Beijing Eye Study 2011 is a population-based cross-sectional study in a rural region and an urban region of Greater Beijing.4 ,5 The Medical Ethics Committee of the Beijing Tongren Hospital approved the study protocol. The only eligibility inclusion criterion was an age of >50 …

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  • Contributors All authors were involved in the design of the study, the collection and statistical analysis of the data, and the writing and final approval of the manuscript

  • Funding Supported by the National Key Laboratory Fund and National Natural Science Foundation of China (No. 81170890)

  • Competing interests None.

  • Ethics approval The Medical Ethics Committee of the Beijing Tongren Hospital approved the study protocol.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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