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Recently, this journal published a paper from Marr et al 1 concerning multi-drug intra-arterial chemotherapy (IAC) for intraocular retinoblastoma. In many centres IAC has quickly garnered exciting interest, emerging as a promising, highly effective alternative for globe conserving treatment.2–4 In our institution, IAC with melphalan (IACM) has been performed since June 2008, and topotecan was added in June 2011. Fifty-nine patients have at least 1 year follow-up. Here we report our results obtained with IACM.
Forty-seven patients (table 1) for a total of 52 eyes with 22 newly diagnosed intraocular retinoblastomas (ND-RTBs) and 30 intraocular retinoblastomas after partial remission and/or relapses after other therapies (PR/R-RTBs) underwent IACM after a multidisciplinary group approval.5 The range of follow-up time is 19–61 months (median 39.6 months).
Competing interests None.
Ethics approval Ethics Committee of Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Provenance and peer review Not commissioned; externally peer reviewed.