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Contributors Substantial contributions to conception and design, acquisition of data or analysis and interpretation of data: JME, DM, AT, LM, JFH. Drafting the article or revising it critically for important intellectual content: JME, DM, PB, GL, LM. Final approval of the version to be published: all authors.
Competing interests None.
Patient consent Obtained.
Ethics approval Regular clinical practice in the setting of a referral centre. Absence of intervention.
Provenance and peer review Not commissioned; externally peer reviewed.
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