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Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis
  1. Xiaogang Wang1,2,
  2. Yali Jia1,
  3. Rebecca Spain3,
  4. Benjamin Potsaid4,
  5. Jonathan J Liu4,
  6. Bernhard Baumann4,
  7. Joachim Hornegger5,
  8. James G Fujimoto4,
  9. Qiang Wu2,
  10. David Huang1
  1. 1Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA
  2. 2Affiliated Sixth People's Hospital Shanghai Jiao Tong University, Shanghai, P.R. China
  3. 3Department of Neurology, Portland VA Medical Center, Oregon Health & Science University, Portland, Oregon, USA
  4. 4Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
  5. 5Pattern Recognition Lab and School of Advanced Optical Technologies (SAOT), University Erlangen-Nuremberg, Erlangen, Germany
  1. Correspondence to Dr David Huang, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239-4197, USA; bjo{at}


Aims To investigate swept-source optical coherence tomography (OCT) angiography in the optic nerve head (ONH) and parafoveal regions in patients with multiple sclerosis (MS).

Methods Fifty-two MS eyes and 21 healthy control (HC) eyes were included. There were two MS subgroups: 38 MS eyes without an optic neuritis (ON) history (MS −ON), and 14 MS eyes with an ON history (MS +ON). The OCT images were captured by high-speed 1050 nm swept-source OCT. The ONH flow index (FI) and parafoveal FI were quantified from OCT angiograms.

Results The mean ONH FI was 0.160±0.010 for the HC group, 0.156±0.017 for the MS−ON group, and 0.140±0.020 for the MS+ON group. The ONH FI of the MS+ON group was reduced by 12.5% compared to HC eyes (p=0.004). A higher percentage of MS+ON eyes had abnormal ONH FI compared to HC patients (43% vs 5%, p=0.01). Mean parafoveal FIs were 0.126±0.007, 0.127±0.010, and 0.129±0.005 for the HC, MS−ON, and MS +ON groups, respectively, and did not differ significantly among them. The coefficient of variation (CV) of intravisit repeatability and intervisit reproducibility were 1.03% and 4.53% for ONH FI, and 1.65% and 3.55% for parafoveal FI.

Conclusions Based on OCT angiography, the FI measurement is feasible, highly repeatable and reproducible, and it is suitable for clinical measurement of ONH and parafoveal perfusion. The ONH FI may be useful in detecting damage from ON and quantifying its severity.

  • Optic Nerve
  • Imaging
  • Retina

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