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Corneal tolerance to micronised mineral pigments for keratopigmentation
  1. Maria A Amesty1,
  2. Jorge L Alio2,
  3. Alejandra E Rodriguez2
  1. 1Department of Ophthalmology, Nottingham University Hospitals, Nottingham, UK
  2. 2Vissum Corporación Oftalmológica, Alicante, Spain
  1. Correspondence to Professor Jorge L Alio, Vissum Corporación Oftalmológica, Avenida de Denia s/n, Alicante 03016, Spain; jlalio{at}


Purpose To study the tolerance and biocompatibility of micronised mineral pigments for corneal cosmetic pigmentation in an experimental animal model.

Methods Corneal intralamellar keratopigmentation was performed in 28 New Zealand white rabbits using micronised mineral pigments. Prophylactic actions using intraoperative antibiotic prophylaxis and gamma radiation of the pigment mixtures were performed to avoid infection. Animals were examined regularly by slit lamp to detect any sign of inflammation, pigment diffusion, colour changes or neovascularisation. Histopathological examination was performed to determine the level of pigment diffusion, the level of inflammation and the presence of neovascularisation.

Results No pigment diffusion or changes in colour, inflammation or neovascularisation were detected in the eyes treated. Histopathological examination corroborated clinical results regarding inflammation. Pigmented corneas showed a good cosmetic appearance without signs of ocular toxicity.

Conclusions Micronised mineral pigments could be a valid alternative treatment for cosmetic keratopigmentation. The intralamellar keratopigmentation technique presented good cosmetic appearance without adverse effects in the eyes treated.

  • Cornea
  • Cosmesis
  • Treatment Surgery

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