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Differences in the topographic profiles of retinal thickening in eyes with and without serous macular detachment associated with diabetic macular oedema
  1. Hannah Shereef1,
  2. Oliver Comyn2,
  3. Sobha Sivaprasad2,
  4. Philip Hykin2,
  5. Gemmy Cheung3,
  6. Nirodhini Narendran1,
  7. Yit Chiun Yang1
  1. 1Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK
  2. 2National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
  3. 3Singapore National Eye Centre, Singapore, Singapore
  1. Correspondence to Yit Yang, Royal Wolverhampton Hospitals NHS Trust, Wednesfield Road, Wolverhampton, WV10 0QP, UK; yit.yang{at}


Purpose To investigate if cases of diabetic macular oedema (DMO) associated with serous macular detachment (SMD) have a different topographic profile of retinal thickening compared with DMO cases not associated with SMD.

Methods Optical coherence tomography scans of 152 eyes from 152 patients with centre-involving DMO and central subfield thickness >350 µm were identified. Measurements were taken of the neural retina at the highest point of thickening within the central subfield (H) and lateral extent of retina thicker than 350 µm (W). Group means were compared between eyes with SMD and eyes without SMD.

Results SMD was present in 55 eyes (36%). H was lower in eyes with SMD than in eyes without SMD (396 µm vs 550 µm, p<0.001) while W was higher in eyes with SMD compared with eyes without SMD (4.74 mm vs 4.18 mm, p=0.011).

Conclusions There were distinct differences in topographical profiles of retinal thickening between eyes with SMD and eyes without SMD. These findings suggest a possible mechanical basis for the pathogenesis of SMD in DMO.

  • Macula
  • Retina
  • Imaging

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