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Retinal thinning and correlation with functional disability in patients with Parkinson's disease
  1. M Satue1,2,
  2. M Seral3,
  3. S Otin1,2,
  4. R Alarcia3,
  5. R Herrero1,2,
  6. M P Bambo1,2,
  7. M I Fuertes1,2,
  8. L E Pablo1,2,
  9. E Garcia-Martin1,2
  1. 1Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain
  2. 2Aragones Institute of Health Sciences, Zaragoza, Spain
  3. 3Neurology Department, Miguel Servet University Hospital, Zaragoza, Spain
  1. Correspondence to Dr Maria Satue, Ophthalmology Department, Miguel Servet University Hospital, C/ Padre Arrupe. Consultas Externas de Oftalmología, Zaragoza 50009, Spain; mariasatue{at}


Aims To determine whether there is an association between retinal thinning and functional rating scales in patients with Parkinson's disease (PD).

Materials and methods Patients with PD (n=153) and controls (n=242) underwent evaluations of the macula and retinal nerve fibre layer (RNFL) using two new-generation Fourier domain optical coherence tomography (OCT) devices (Cirrus, Carl Zeiss Meditec, Dublin, California, USA; Spectralis, Heidelberg Engineering, Heidelberg, Germany). PD severity was assessed using the Schwab-England Activities of Daily Living scale, the Unified Parkinson Disease Rating Scale, the Hoehn and Yahr (HY) scale. Retinal and RNFL thicknesses were compared between patients and controls. Correlations between structural parameters and the scores of the neurologic scales were evaluated.

Results RNFL parameters were significantly reduced in patients with PD, especially when using the Spectralis OCT device. All macular parameters, except for foveal thickness, differed significantly between controls and patients with PD (p<0.001). HY scores were significantly and inversely correlated with all macular parameters when measured with the Spectralis OCT device (p<0.05) and with RNFL thickness when measured with the Cirrus OCT device (nasal quadrant, sectors 2 and 5).

Conclusions The neurodegeneration caused by PD can be detected using Fourier domain OCT. RNFL and macular thicknesses correlate with PD severity.

  • Optic Nerve
  • Retina
  • Pathology

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