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Transdermal androgen patches in evaporative dry eye syndrome with androgen deficiency: a pilot study
  1. Mayank A Nanavaty1,
  2. Matthew Long2,
  3. Raman Malhotra1
  1. 1Corneoplastic Unit, Queen Victoria Hospital, East Grinstead, UK
  2. 2Department of Gynaecology, Queen Victoria Hospital, East Grinstead, UK
  1. Correspondence to Raman Malhotra, Corneoplastic Unit, Queen Victoria Hospital, East Grinstead RH19 3DZ, UK; raman.malhotra{at}

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Androgens exert a significant effect on neutral and polar lipids in human meibomian gland secretions, and these hormonal effects may be mediated through androgen receptors causing tear film instability and evaporative dry eye (EDE).1–3 Consequently, the androgen deficiency that occurs during menopause, ageing, and even Sjogren's syndrome4 may contribute to meibomian gland dysfunction and EDE often observed in these conditions.5

Having frequently identified low serum testosterone in patients with EDE, in 2010, with specialist gynaecological consultation, we began recommending the use of a transdermal androgen patch (Intrinsa, Procter and Gamble, UK) therapy for patients attending an eye clinic with persistent and symptomatic EDE found to have low serum testosterone. We report the outcomes of our audit.


A retrospective …

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  • This data was presented at American Academy of Ophthalmology Conference, Chicago in November 2012.

  • Contributors MAN: data collection, analysis, manuscript drafting and critical review. ML: critical review of the manuscript. RM: data collection, analysis, manuscript drafting and critical review.

  • Competing interests None.

  • Ethics approval Approval obtained from Audit department at Queen Victoria Hospital, East Grinstead, UK.

  • Provenance and peer review Not commissioned; externally peer reviewed.