Article Text

Download PDFPDF
Central toxic keratopathy: a clinical case series
  1. Montserrat Garcia-Gonzalez1,
  2. Miguel A Teus2,3
  1. 1 Vissum Santa Hortensia, Madrid, Spain
  2. 2 Hospital Universitario ‘Príncipe de Asturias’, University of Alcalá, Alcalá de Henares, Madrid, Spain
  3. 3 Novovisión Madrid, Madrid, Spain
  1. Correspondence to Dr Montserrat Garcia-Gonzalez, Vissum Santa Hortensia, Santa Hortensia 58, Madrid 28002, Spain; montseggonz{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Dear Editor,

We read with great interest the article by Marí Cotino and associates1 about an epidemic of central toxic keratopathy (CTK) that occurred after laser in situ keratomileusis (LASIK), presumably caused by the change of the brand of the surgical gloves. Although its aetiology is unknown, CTK has common features with grade IV diffuse lamellar keratitis, but it is widely accepted that it represents a separate clinical entity. It has received other names in the literature, such as ‘central flap necrosis’.

Marí Cotino et al 1 state in their article that CTK does not have a specific treatment and that the clinician must …

View Full Text


  • Contributors Both the authors have made substantial contributions to conception and design, writing the article, and final approval of the version to be published.

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.