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In the recent article published in British Journal of Ophthalmology,
reported two cases of desegmentation of Ozurdex implant in vitreous
In this report, the authors comment that Allergan confirmed that fractured
implants in the applicator have not been found to date during the quality
We recently reported2
also two cases of implant fragmentation in response t...
also two cases of implant fragmentation in response to a
Roy et al3
. These authors reported a broken implant at the end of the injection.
They postulate that the reason for breakage could be friction at the tip
needle or some drug loading problem
Our first case showed similar fundus image, dexamethasone implant
within vitreous cavity one month after injection In the second case, the
broken after the ejection during an instructional wet-lab, outside
conditions. This event was recorded in a video that is available with our
Therefore, this video proves that for a break to happen during the
is utterly feasible and .taking into account the comment of Allergan,
that the friction at the tip of the needle during de ejection must be the
We agree with the authors that these patients with defragmented implants
should be followed up carefully to monitor for unexpected complications,
more in patients with zonular dehiscence.
1. Agrawal R, Fernandez-Sanz G, Bala S, et al. Desegmentation of
Ozurdex implant in vitreous cavity: report of two cases. Br J Ophthalmol.
2. Cabrerizo J, Garay-Aramburu G. Re: intravitreal dexamethasone implant
fragmentation.Can J Ophthalmol. 2013;48:343.
3. Roy R,HegdeS. Split Ozurdex implant: a caution. Can JOphthalmol.