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Validation of a new static perimetric thresholding strategy (GATE)
  1. Annette Franziska Luithardt1,
  2. Christoph Meisner2,
  3. Matthias Monhart3,4,
  4. Elke Krapp1,
  5. Andrea Mast1,
  6. Ulrich Schiefer1,5,6
  1. 1Department of Ophthalmology, University of Tübingen, Germany
  2. 2Institute of Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany
  3. 3Formerly Haag-Streit Inc., Köniz, Switzerland
  4. 4Carl Zeiss Meditec Inc., Feldbach, Switzerland
  5. 5Research Institute for Ophthalmology, University of Tübingen, Tübingen, Germany
  6. 6Faculty of Optics & Mechatronics, Competence Center “Vision Research”, Study course “Ophthalmic Optics & Audiology”, University of Applied Sciences, Aalen, Germany
  1. Correspondence to Annette Franziska Luithardt, Metzenwiesenstr. 11, 71384 Weinstadt, Germany; annetteluithardt{at}


Aims To validate the EyeSuite version of German Adaptive Threshold Estimation (GATE), a new thresholding algorithm for automated static perimetry.

Methods Specification of agreement and its clinical evaluation as validation criteria. Comparison of local differential luminance sensitivity (DLS) and test time values between the prototype version of GATE (GATEp) and a clinical trial version, implemented in EyeSuite (GATEe), by means of modified Bland–Altman plots. All examinations were performed on the Octopus 900 perimeter (Haag-Streit Inc., Köniz, Switzerland). Visually impaired patients (anterior ischaemic optic neuropathy [n=3], glaucomatous optic neuropathy [n=15], (post-)chiasmal visual pathway lesion [n=6], retinitis pigmentosa [n=6]) were either tested with grid 30A (30° excentricity, 83 test locations) or grid 84NO (90° excentricity, 109 test locations, patients with RP only).

Results The comparison of local DLS values showed good-to-acceptable agreement between GATEp and GATEe (bias <2 dB, limits of agreement [LOA] <5 dB) and very good repeatability for GATEp (bias <0.5 dB, LOA<3 dB). Median test times for GATEp and GATEe were 7.8  and 8.8 min for the 30° grid and 6.7  and 7.8 min for the 90° grid.

Conclusions GATEp and GATE, implemented in the commercially available EyeSuite software package (GATEe), show good agreement regarding local differential luminance sensitivity. GATEe can thus be also recommended for clinical practice.

Clinical trial number NCT01265628.

  • Diagnostic tests/Investigation
  • Field of vision
  • Glaucoma
  • Visual pathway

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