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Properties and clinical utility of topotecan fluorescence: uses for retinoblastoma
  1. Jasmine H Francis1,2,
  2. Brian P Marr1,2,
  3. Paula Schaiquevich3,
  4. Michael G Kellick4,
  5. David H Abramson1,2
  1. 1Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
  2. 2Department of Ophthalmology, Weill Cornea Medical Center, New York, New York, USA
  3. 3Unidad de Farmacocinética Clínica, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina
  4. 4Pediatric Pharmacy Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
  1. Correspondence to Jasmine H Francis, Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA; francij1{at}


Topotecan fluoresces when exposed to ultraviolet (UV) light. Our observations with UV light in retinoblastoma cases has allowed us to minimise and manage inadvertent skin contact, guide periocular injections and leakage from such injections and document conjunctival contact after periocular injection in addition to demonstrating the drug in the vitreous after intravitreal injection. The technique is safe, inexpensive and easy to perform.

  • Imaging
  • Pharmacology
  • Treatment other
  • Vitreous
  • Drugs

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