You are here

Article Text

Article menu
Download PDFPDF
Innovations
Properties and clinical utility of topotecan fluorescence: uses for retinoblastoma
  1. Jasmine H Francis1,2,
  2. Brian P Marr1,2,
  3. Paula Schaiquevich3,
  4. Michael G Kellick4,
  5. David H Abramson1,2
  1. 1Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
  2. 2Department of Ophthalmology, Weill Cornea Medical Center, New York, New York, USA
  3. 3Unidad de Farmacocinética Clínica, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina
  4. 4Pediatric Pharmacy Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
  1. Correspondence to Jasmine H Francis, Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA; francij1{at}mskcc.org

Abstract

Topotecan fluoresces when exposed to ultraviolet (UV) light. Our observations with UV light in retinoblastoma cases has allowed us to minimise and manage inadvertent skin contact, guide periocular injections and leakage from such injections and document conjunctival contact after periocular injection in addition to demonstrating the drug in the vitreous after intravitreal injection. The technique is safe, inexpensive and easy to perform.

  • Imaging
  • Pharmacology
  • Treatment other
  • Vitreous
  • Drugs
View Full Text

http://dx.doi.org/10.1136/bjophthalmol-2015-306633

Statistics from Altmetric.com

    View Full Text

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Copyright information:

    Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions