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Association between the prevalence of obstructive sleep apnoea and the severity of keratoconus
  1. Mohammad Naderan1,
  2. Farzaneh Rezagholizadeh2,
  3. Masoome Zolfaghari1,
  4. Morteza Naderan1,
  5. Mohammad Taher Rajabi3,
  6. Mohammad Amin Kamaleddin4
  1. 1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  3. 3Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences,Tehran, Iran
  4. 4Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
  1. Correspondence to Dr Mohammad Naderan, School of Medicine, Tehran University of Medical Sciences, Keshavarz Boulevard, Tehran, Iran; moh{at}


Aim The purpose of this study was to determine the association between prevalence of obstructive sleep apnoea (OSA) in patients with keratoconus (KC) and the severity of KC.

Methods Six-hundred and sixteen patients with KC and 616 patients without KC in the control group were enrolled in this prospective case–control study. Both groups were matched by age, gender, and body mass index (BMI). The Berlin Questionnaire was administered in both groups. Keratometric and topographic measurements of the KC eyes were recorded.

Results Seventy-six (12.3%) and 40 (6.5%) patients were identified as high risk for developing OSA in KC and control groups, respectively (p<0.001). Family history of OSA and BMI were the risk factors for OSA in the KC group, while in the control group the only risk factor for OSA was the patient's gender. Patients with KC with a high risk of OSA had a significantly higher mean K, flat K, steep K (p<0.05), and a thinner corneal thickness (p<0.05). The severity of KC decreased in both OSA groups except for the grade 4 of high risk group which was the second most frequent group after grade 1 (p=0.005).

Conclusions Our study revealed that patients with KC are at increased risk of developing OSA, and patients with KC who are at higher risk of developing OSA may have more severe KC.

  • Cornea

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