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We congratulate Messenger et al. for their study entitled
'Characterization of uveitis in association with multiple sclerosis'.
The authors investigated clinical and demographic characteristics of
multiple sclerosis (MS) patients with uveitis. The study has significant
results including the ratios of anterior, intermediate and posterior
uveitis in this group of MS patients.
We found out that 54%...
We found out that 54% of MS patients without any visual symptoms and
signs had significantly delayed P100 latency in pattern visual evoked
potential s (PVEP). This high ratio may mean that clinical symptoms and
signs resemble an iceberg in MS world. This finding should force the
researchers to use ocular electrophysiologic findings especially in
researches including ocular involvement. Therefore, I want to ask to the
authors whether they have PVEP results of the patients, but not only the
patients included in the study. In case they have, would they mind to
investigate the relation between P100 latency and the presence/absence
of uveitis in the patients. The authors have a significant number of MS
patients. They have the data whether each patient has uveitis. If they
have PVEP results too, this gives them an invaluable chance. This is
important, because if patients with higher P100 latency have a higher risk
of uveitis, then these patients may be suggested to have ophthalmic
examinations more frequently than patients with normal P100 latency. That
kind of investigation would also add significant contribution to the MS
1. Messenger W, Hildebrandt L, Mackensen F, Suhler E, Becker M, Rosenbaum
JT. Characterisation of uveitis in association with multiple sclerosis. Br
J Ophthalmol 2014 doi: 10.1136/bjophthalmol-2014-305518[published Online
First: Epub Date]|.
2. Gundogan FC, Demirkaya S, Sobaci G. Is optical coherence tomography
really a new biomarker candidate in multiple sclerosis? - A structural and
functional evaluation. Investigative Ophthalmology & Visual Science
2007;48(12):5773-81 doi: Doi 10.1167/Iovs.07-0834[published Online First: